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1.
Rev. méd. Chile ; 145(10): 1342-1348, oct. 2017. graf
Article in Spanish | LILACS | ID: biblio-902449

ABSTRACT

Primary colorectal lymphoma is a rare form of presentation of gastrointestinal tract lymphomas. Inflammatory bowel disease and its treatment are risk factors for its development. We report a 47-year-old male patient with Ulcerative Colitis of two years of evolution, treated initially with azathioprine and later on with infliximab. Due to a relapse in symptoms after the second dose of infliximab, a new coloncoscopy was performed showing a rectal ulcerative lesion, corresponding to a large cell Non-Hodgkin's Lymphoma. The patient was successfully treated with RCHOP chemotherapy (Rituximab cyclophosphamide doxorubicin vincristine prednisone). He is currently in disease remission.


Subject(s)
Humans , Male , Middle Aged , Rectal Neoplasms/etiology , Rectal Neoplasms/pathology , Colitis, Ulcerative/drug therapy , Lymphoma, Large B-Cell, Diffuse/etiology , Lymphoma, Large B-Cell, Diffuse/pathology , Immunosuppressive Agents/adverse effects , Rectal Neoplasms/diagnostic imaging , Azathioprine/adverse effects , Vincristine/administration & dosage , Biopsy , Gastrointestinal Agents/adverse effects , Prednisone/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Doxorubicin/administration & dosage , Lymphoma, Large B-Cell, Diffuse/diagnostic imaging , Cyclophosphamide/administration & dosage , Rituximab/administration & dosage , Infliximab/adverse effects , Positron Emission Tomography Computed Tomography
2.
ARS med. (Santiago, En línea) ; 42(1): 61-67, 2017. Tab
Article in Spanish | LILACS | ID: biblio-1016384

ABSTRACT

La anemia es una condición altamente prevalente a nivel mundial y, el déficit de hierro, la causa más frecuente, sin excepción; la mujer embarazada está particularmente en riesgo dada la mayor demanda de hierro que la gestación significa. La anemia se asocia a mayor morbilidad y mortalidad materno-perinatal. En mujeres embarazadas sin anemia, la prevención, mediante el uso de multivitamínicos que contienen hierro en dosis de 30-60 mg de hierro elemental, ha demostrado ser efectiva y se recomienda durante todo el embarazo. En casos de anemia, el diagnóstico de déficit de hierro se establece cuando la ferritina es menor a 30 mg/L y/o la saturación de transferrina es menor a 20 por ciento. La severidad de la anemia y la situación temporal en el embarazo, son factores modificantes del tratamiento. En mujeres embarazadas, con hemoglobina ≥9.0 g/dL y que tengan <34 semanas de embarazo, la indicación es tratamiento con hierro oral, en dosis de 100 mg al día, en días alternos, hasta normalizar los parámetros antes mencionados. Si la hemoglobina es <9.0 g/dL, o el embarazo es ≥34 semanas, el uso de hierro intravenoso ha demostrado ser más efectivo en corregir la anemia y el déficit de hierro y en disminuir la morbilidad materno-perinatal. En estos casos, sugerimos el uso del hierro carboximaltosa, dado su perfil de seguridad y efectividad favorable. Recomendamos conocer y practicar estas recomendaciones para el diagnóstico y manejo de la anemia por déficit de hierro durante el embarazo.(AU)


Anemia is a highly prevalent condition worldwide, and iron deficiency the most frequent cause, without exception; pregnant women are particularly at risk given the increased iron demand of gestation. Additionally, anemia directly correlates with increased maternal-perinatal morbidity and mortality. For non-anemic pregnant women, prevention using 30-60mg of elemental iron-containing multivitamins, has proven effective, and is recommended throughout all pregnancy. In the case of anemia, the diagnosis of iron deficiency is established when ferritin is under 30 mg/L or when transferrin saturation is under 20 percent. The severity of the anemia and the time course of pregnancy, are treatment determining factors. Pregnant women, with hemoglobin ≥9.0 g/dL, and <34 weeks-pregnant, are best treated with oral iron, at dose of 100 mg of elemental iron, on alternate days, until all altered parameters are corrected. Otherwise, when hemoglobin is <9.0 g/dL, or pregnancy is ≥34 weeks, intravenous iron has demonstrated to be more effective to normalize anemia, iron deficiency and diminish maternal-perinatal morbidity. In those cases, we suggest the use of carboximaltose iron, due to its favorable safety and efficiency profile. We recommend knowing and practicing these recommendations for the diagnosis and management of iron deficiency anemia during pregnancy.(AU)


Subject(s)
Humans , Female , Pregnancy , Pregnancy , Anemia , Chile , Disease Management , Diagnosis , Ferritins , Iron
3.
Rev. méd. Chile ; 143(6): 809-811, jun. 2015. tab
Article in Spanish | LILACS | ID: lil-753523

ABSTRACT

Thrombotic thrombocytopenic purpura, an immune/non-immune thrombotic microangiopathy (TTP/TMA) is associated with high morbidity and mortality, even with appropriate treatment. In patients refractory to standard treatment with plasmapheresis there is no certainty about the best therapeutic strategy. This report shows our experience in eight refractory patients who survived after treatment with rituximab.


Subject(s)
Adult , Female , Humans , Male , Middle Aged , Young Adult , Purpura, Thrombotic Thrombocytopenic/drug therapy , Rituximab/therapeutic use , Recurrence , Retrospective Studies , Rituximab/pharmacokinetics
4.
Univ. psychol ; 14(1): 189-204, ene.-mar. 2015. ilus, tab
Article in Spanish | LILACS | ID: lil-765716

ABSTRACT

Este estudio valida, a nivel confirmatorio, la escala de comportamiento ecológico que mide la realización de acciones que procuran proteger y/o conservar el medio ambiente y las escalas de las variables utilizadas en la literatura para explicar dicho comportamiento: el conocimiento medioambiental, las creencias asociadas a la preocupación ambiental, los valores y las intenciones de comportamiento ecológico. Sobre una muestra de 497 individuos en España, seleccionada por muestreo no probabilístico por cuotas, se analizan las propiedades psicométricas de las escalas mediante análisis factorial exploratorio y confirmatorio. Los resultados muestran el carácter multidimensional de las escalas de conocimiento (conocimiento básico [CB] y conocimiento experto [CEX]) y comportamiento ecológico (gestión ecológica de basuras [GEB] e implicación medioambiental [IM]) y unidimensional del resto de medidas. La validación a nivel confirmatorio de las escalas para las variables seleccionadas proporciona una importante contribución para futuros trabajos de investigación.


This study validates using confirmatory factor analysis the scale of ecological behavior, which measures the implementation of actions that intend to protect and/or preserve the environment, and the scales of variables used in literature in order to explain that behavior: environmental knowledge, beliefs associated with environmental awareness, values and ecological behavior intention. Using a sample of 497 individuals in Spain selected by non-probability quota sampling, the psychometric properties of the scales were analyzed by exploratory and confirmatory factor analysis. The results show the multidimensional nature of knowledge (basic knowledge -CB and expert knowledge -CEX) and environmental behavior (waste management -GEB and environmental implication -IM) scales and the one-dimensional nature of the rest of measures. The validation, using confirmatory factor analysis of the selected variables, provides an important contribution to future research.


Subject(s)
Ecology , Environment
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